Friday, September 05, 2008

Everything Changes But You: Neuroplasticity and Christian Belief, Klee and De Sté

Heraclitus' toe-dipping exercise might have encompassed the change of status that comes with marriage, the change in frequency of nights out that accompanies each new baby, the change of jobs that comes with being bored with the old one, the change of singer/musician for the night on account of the usual one being indisposed, the change in how we have our way with cocktails and chocolates...following the Moskva down to Gorky Park on an August summer night...

But the old Greek had nothing on neuroplasticity. If the hypotheses of neuroplasticity are indeed accurate, then the previously entrenched idea of the immutability of the brain (and hence of thoughts, personality, traits, talents etc) must itself be overhauled. Far from being hardwired from birth or childhood, or enslaved by genes, the adult brain can and does change physiologically according to experience, thinking and education.

Newtonian physics (as distinguished from the theories of the apple-pelted Newton himself) has been accused of promoting the tyranny of determinism in various fields including biology and neuroscience. As the discovery of quantum physics replaced belief in deterministic systems with probabilistic systems, it is also said that epiphenomenalism, the idea that consciousness has no casual impact on the brain but that the neurons fire first before the mind experiences decision-making, has now been replaced by neuroplasticity.

Timothy O'Dwyer at Bar Stop, Devonshire Road
The first time I tried to explain the concept of neuroplasticity, we were at Bar Stop, waiting for good mates to arrive and also Tim O'Dwyer and his saxophone in place of Anne Weerapass. A hopefully more lucid explanation follows.

Observing his father's recovery from a massive stroke, Paul Bach-y-Rita realised that our brains are more flexible than localisation would have us believe. His father recovered so well that he returned to lecturing at college, remarried, went hiking and travelling and enjoyed a fully energetic life until his death (from a heart attack while climbing a mountain). The autopsy revealed that his father had in fact been doing all this on 3% of the nerves that run from the cerebral cortex to the spine; the rest had been destroyed in the stroke. Where neurologists used to say that the visual cortex in our occipital lobe processes vision and the auditory cortex in our temporal lobe processes hearing, Paul showed that these areas are plastic and capable of processing a variety of input not just visual or auditory as the case may be. The blind can, for example, learn to "see" with their tongues and ferrets who had their retina fibres wired to their auditory pathways learned to "see" with their auditory cortex (Discover, 2003).

(But I guess while this sort of "see"-ing approximates the product of input from our retinas in the sense of perception and interpretation of light, it is unlikely to result in the exact same product that is derived from the retinas being connected by optic nerves to our visual cortex. I wonder then, when one sees with the tongue, if colours and shapes are interpreted as distinctive tastes. Anyway, whew. So it's not too weird that music and the sounds of certain instruments and voices has always been to me sometimes synonymous with certain shapes and lines of varying widths and colours, and also certain textures and tastes. Maybe there's a living to be made translating music to pleasing visuals to the tune of Tom Hingston, who did awesome cover work for one of my favourite bands, Massive Attack. Maybe such cover work can even be multimedia - encompassing texture and taste.)

Timothy O'Dwyer at Bar Stop, Devonshire Road
Later on, Michael Merzenich discovered competitive plasticity. The conventional view was that the brain was only plastic for a period of time (the critical period) during childhood after which it is too rigid to change its structure on a large scale, hence the Mozart Effect/Montessori/enrichment class crush so often observed amongst the progeny of parents who only want "the best" for them. Competitive plasticity suggests that adults have difficulty learning another language, musical instrument or skill not because their brains have already been hardwired, but because cerebral real estate is competitive and any bit left vacant is quickly taken over for other uses. So if two languages had been learned at the same time, then both would have shared in more or less equal parts, that bit of real estate.

Merzenich then started Posit Science - a company devoted to helping people ensure that occupancy levels continue to be high in their little plot of grey matter.

How to transfer occupancy in cerebral real estate? The Hebbian learning axiom that "neurons that fire together wire together" summarises the theory that "the persistence or repetition of a reverberatory activity tends to induce lasting cellular changes that add to its stability"; repetition helps neurons develop strong connections with one another when they are activated at the same moment in time, thereby leading to synaptic strength and a change in grey matter residency and therefore thought patterns and resultant behaviour.

This theory is the basis of programmes for children with learning disabilities in Arrowsmith School, and the Fast ForWord programme by Merzenich's other company, Scientific Learning.

If mere thinking or imagining, immaterial actions, leaves material traces, if each thought alters the physical brain, then it possible to sculpt our brains as we sculpt our bodies.

Klee, Bar at Wessex Village, Portsdown Road
My Drink Driving Spot Ran Over Your God Spot
So what of belief then? When determinism was in, it was fashionable to advocate a God Spot, or God Gene, to explain why certain people believed in a higher power and others didn't; a gene which gives these types a predisposition to episodes interpreted by some as religious experiences. There were several detractors including one Carl Zimmer who dismissed such claims saying that, given the low explanatory power of VMAT2, it would have been more accurate for the author of The God Gene: How Faith Is Hardwired Into Our Genes, Dean Hamer, to have named his book "A Gene That Accounts for Less Than One Percent of the Variance Found in Scores on Psychological Questionnaires Designed to Measure a Factor Called Self-Transcendence, Which Can Signify Everything from Belonging to the Green Party to Believing in ESP, According to One Unpublished, Unreplicated Study".

Grape-tini at Klee, Bar at Wessex Village, Portsdown Road
Scientific Study That Brain Activation Similar in Monks in Deep Meditation on Compassion and Friends Downing Cocktails at Klee Leads to Mixology Being Recognised As Official Religion
It is always good copy for the media to stir science up against what they term "religion" and sprinkle the word "controversial" liberally onto the mix. So who can resist pouncing on the theory of neuroplasticity as evidence that belief in God is nothing more than a mere rearrangement of synapse-firing without any basis in external reality, brought on no doubt by tyrannical repetition by relatives, friends and cultists.

Neurotheology (alas! Memories of Secondary 2 literature text horror, Aldous Huxley,'s Island!) purports to demonstrate that religious experience (and therefore the truth of religions) can be explained by cognitive neuroscience. Statisticians and fans of Freakonomics would quickly intone, correality (if any) does not necessarily mean causality.

Furthermore, neurotheologians mistakenly identify religion with specific experiences and feelings. Very few thoughtful Christians base their belief on some experience of a "mystical union with God" or transcendent rapture.

Plus, there is enough external evidence to prove the veracity of Christian truth claims. Oh but oooh, can we be sure that cognitive faculties are reliable enough to interprete that which we claim they interprete? In addition to the many obvious and common-sensical epistemological arguments, Alvin Plantinga calmly notes, in his usual fashion, that this sort of thinking is in fact itself subject to the rationality hiccups. (You had me at "vituperation", Mr. Plantinga.)

Chocolates from Stefano Deiuri's De Ste, The Riverwalk
Scientists Report Need for Further Research on Whether Increased Ingestion of Cocoa Matter Aids in Neuroplastic Sanctification Process
Now that that's out of the way, what is of interest is how neuroplasticity, *if true*, interacts with the event Christians term "conversion" and the process known as "sanctifcation". Laterz.

BarStop
6 Devonshire Road
Singapore 239844
Tel: 6735 6614

Klee
Klee, Bar at Wessex Village, Portsdown Road
5B Portsdown Road #01-04
Singapore 139311
Tel: 6479 6911
No menu, no wine, no beer, no straight shots, no bar snacks, no website but check out their Facebook fan site. Eh, said the drinking buddy, how to survive like that?

The premise of the place is that Singapore is a market mature enough for "bespoke cocktails". Why splash cash on hair-on-chest drinks that have to be thrown down the back of your throat because they are the embodiment of such great foulness? The cocktails indeed score nicely on the alcohol percentage test but remain smooth with layered flavours that reveal themselves through the life of the drink or mouthful. Earnest and friendly (but not overly-chatty) mixologists happily explain each ingredient as they muddle fresh fruits, pour in measures of Smirnoff Black, Belvedere, Bombay Sapphire gin or fruit liquers or a bit of Bols blue (I got a bottle of this duty-free on the ferry to Amsterdam and we had great fun back at halls because it turned our tongues blue and lent itself to all sorts of corny coastal/sea-themed cocktails) for a China Blue. On offer, as far as the memory goes were strawberrytinis, grape-tinis, kiwitinis, grapefruit martinis, Earl Grey martinis, mojito sherbets (mango this week, but, said Wijaya, I found some blackberry sherbet in the supermarket so maybe blackberry next week) made with freshly squeezed lime juice muddled with sugar and fresh mint leaves, cosmo royal, secret garden, flirtinis (somewhat like a French martini? It's the Chambord layer at the bottom of the glass). They've also connected their ice machine to a Hyflux Reverse Osmosis Drinking Water System to produce pure distilled ice that is free from contaminants (kinda like NEWater, no?).

Anyway, only managed to sample 2.2 of the unwritten menu, fearing that I might need to take the wheel. Fortunately, designated driver was sober enough for me to warm the passenger seat.

Still, there was the organic enjoyment of watching drinks being prepared in the pit. Wijaya said their bottle of Pimms had been relak-ing one corner since opening day because it was difficult to make a good cocktail out of its contents. Wonder if we could do a sort of volatile compound test, the way food pairings are done in molecular gastronomy, to discover new mixes for cocktails with ingredients that share common odorants or other organoleptic qualities. To poshify our lab work, we could market it as "molecular mixology". Imagine: pineapple, blue cheese and white wine! Oyster and kiwi! Liver and Jasmine! A few months ago, I discovered, after accidentally leaving a punnet of strawberries in the car, that hot strawberries smelled like tomatoes. Hot strawberry juice instead of tomato juice in your Bloody Mary p'haps? The cocktail experimenting paws were twitching.

DeSté, by Stefano Deiuri
20 Upper Circular Road
#01-39/41
The Riverwalk
Singapore 058416
Tel: 6536 1556
Intriguing experiments with chocolates. Choices include crunchy exotic fruit salad (pineapple, mango, peach), Cartagena (passionfruit and fleu de sel-caramel), lemon-mint, black sesame and ginger-lime, olive oil (!), rock chocolate (pumped full of air for light, melt-in-the-mouth texture)... Interesting looking cakes too. Curiousity wants to ring its doorbell repeatedly then run straight to the kitchen through the opened door.

The Brain That Changes Itself, Norman Doidge
Written in an enthusiastic, repetitive, American telemarketeering, individuals-are-in-control-of-their-lives style. I suppose time and even more research will tell if claims within are true?

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Thursday, May 31, 2007

Science As Dictatorship?

Water and "The First 3 Minutes"
My nan used to enjoy a nip of brandy and a bit of Readers' Digest-if before bed, heart-warming stories for a peaceful night's rest. I know of others who turn pages of the Bible for their soporific nightcap. Reckoning the Scriptures far too mind-swirling, my preferences used to run to popular science rags: New Scientist, Popular Science, Nature, Scientific American, American Scientist, Technology Review, and Astronomy, for a nice tuck-in. (Flips on urban conjecture and architectural speculation make lovely graphic-rich bedtime stories as well, but more another time.)

Pop science mags are what a dish of warm milk might be to a cat (though probably not Schrodinger's): yummy, lappable, wholesome, comforting.

They are a celebration of the richness of life, the wealth of the known universe (whose boundaries keep expanding deliciously), the magnificence of the cosmos, the spot of light on the mysteries of the deep dark sea, the beauty of the quantum and infinity in a grain of sand, the spawning sprawling fields of astrobiology and nanotechnology.

They comfort their readers with the implication that life can only get better with the advance of science: breakthroughs in cures for cancer and Alzheimers', technological progress that'll make life cushier (and cars flashier and spiffier), conquering the wider universe for the benefit of the human race (especially the space tourism industry), achieving washboard stomachs in 12 easy steps in 2 weeks (just in time for beach volleyball in the summer).

They are lovely saucers of Jersey cream that purr,"Lap it up, lads! We humans are at the helm!" Given enough time, enough manpower, enough research dollars, enough perseverance, enough studies presented at conferences, we can understand most things and Stephen Hawking will have his Theory of Everything and his mobility (and I don't mean a bit of a flail-about in zero-G with nurses in attendance). With this greater knowledge we will be able to steer our own destiny: we will mod our genes to re-wire human beings, we will eliminate the causes of diseases, we will know which sensory/experiential buttons to push to obtain desired social behaviour; with GM crops we will eliminate poverty, with united effort and many conventions we will stop hurting the environment; we will ensure the survival of our life on earth by shooting down asteroids that threaten our extinction (remember them dinosaurs!); our children will inherit a cleaner world; we will know how to live longer by moderating our eating; we will harness singularities and master time; we will tame our inner life with psychology; and perhaps (although few expressly promise such a thing) one day, we may never have to die.

Like many fairytales however, one suspects that the conclusion to the story isn't quite the happily-ever-after we would like.

Aside from the slight-problem-of-technology-in-corrupt-hands dystopias prophesied by Aldous Huxley, George Orwell et al and practical concerns about regulating inter-stellar warp-drive traffic, it is the fundamental validity of science itself as final arbiter of objective truth that is of great concern.

We have come to assume that anything under the auspices of science must surely be a true explanation of reality. (Wherefrom emerge such statements as:"If in fact it is true - and I've asked doctors this - that you are genetically born a homosexual, because that's the nature of the genetic random transmission of genes, you can't help it.")

Midgley with Oyster Mee Sua
A Midge of Dawkins-bashing with my oyster mee sua, please

If as T.S. Eliot's Becket says, "humankind cannot bear very much reality", what is the reality that humans find intolerable? The bright illuminating light of science on the world that causes outdated superstitious religions to find solace by sticking their head in the sand? Or our fearful lack of understanding of and control over the sheer vastness and complexity of the universe that drives us to the blind worship of science?

How much have we mindlessly bought into the spin about the Enlightenment!, the Dawn of Knowledge!, the Age of Reason!, the Autonomy of Humankind!, the Epitome of True Knowledge!, the Eschatology of the Test-tube!?
  • How much are scientific theories exact statements of fact and how much are they short stories about existing facts, romantic explanations of natural phenomena? How blinkered in explication are their propositions, say, of the wave-particle duality of light?
  • What is the basis, for example, for the zeitgeist flavour of this decade: determinism? How valid is the fatalism that who we are has already been determined by nature and nurture, our genes and our early environment?
  • Observer effect and Heisenberg uncertainty principle aside, how objective are researchers? How much are their interpretations influenced by existing presuppositions and political agenda?
  • How far the purported omnicompetence of science? How valid the excursions of science to areas such as value, morality and meaning? Does science really undermine the theories of value, morality and meaning? If science cannot measure value, morality or meaning, do they not exist? If ears do not detect colour, do colours not exist?
Pot Noodles and "Beast and Man"

The quarrel is not with science per se which has proven fairly decent for air-conditioning and cross-continent Skype-ing with loved ones, nor is it about taking the whip to the much-flogged horse of dark-minded Christianity fighting a desperate rear-guard battle against the blonde-haired blue-eyed juggernaut of Reason, nor is it some Keatian lament (according to popular (mis)interpretations of Lamia) about Newton unweaving the rainbow and destroying beauty in the universe.

It is that what is mere theory and hypothesis, mere world-picture and metanarrative myth, is taken as absolute truth. It is that its proponents tout it the sole source of rationality (read: reality) in this otherwise mindless world. It is about the arrogance of science worshippers, daydreaming of omniscience, presuming to extend the rule of Science solely and absolutely over all areas of life; it is about the tyrannical reductivism of scientific methods of thought upon unsuitable areas such as ultimate meaning; it is that we let ourselves, without so much as a whimper, be led by the nose and governed and have our lives mapped by something as unworthy as this.

PS:
Strawberry Slush
Pop science does give you useful excuses tell you useful stuff, like how mixing lovely sweet red strawberries with your choice of leftover alcohol gives you a potent antioxidant slush. And antioxidants, as everyone knows, not only mod your insides to make you smell better to your cat, they also endow you with the ability to watch an entire episode (a whole episode! beginning to end!) of America's Next Top Model. Without getting hernia.
America's Next Top Model

PPS: Clearly, ethanol does shrink brains.
Clearly, alcohol shrinks brains! ;-)

PPPS:
...the wrath of God is revealed from heaven against all ungodliness and unrighteousness of men, who by their unrighteousness suppress the truth. For what can be known about God is plain to them, because God has shown it to them. For his invisible attributes, namely, his eternal power and divine nature, have been clearly perceived, ever since the creation of the world, in the things that have been made. So they are without excuse. For although they knew God, they did not honour him as God or give thanks to him, but they became futile in their thinking, and their foolish hearts were darkened. Claiming to be wise, they became fools, and exchanged the glory of the immortal God for images resembling mortal man and birds and animals and reptiles. (Romans 1:18-23)

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Saturday, December 10, 2005

Coloured Bubbles and 有一位神

May I just say that when it is a gloriously hot and sunny morning and a soft sea breeze is blowing and you know that for just a while you and your friends might at least have been doing your duties as good and faithful servants and also that coloured bubbles have been invented
then your earworm cannot help but sing the song that Boon Yong sang at his ordination:
(1)
有一位神
有權能創造宇宙萬物
也有溫柔雙手安慰受傷靈魂
有一位神
有權柄審判一切罪惡
也有慈悲體貼人的軟弱


(2)
有一位神
有權能創造宇宙萬物
也有溫柔雙手安慰受傷靈魂
有一位神
高坐在榮耀的寶座
卻死在十架挽救人墮落

有一位神
我們的神
唯一的神
名叫耶和華
有權威榮光
有恩典慈愛
是昔在今在永在的神

Woohoo! ZoukOut later.

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Wednesday, July 13, 2005

Return to Flight

Last week, NASA slammed a probe into comet Tempel 1 ostensibly to gather data that they hoped would answer questions about the creation of the solar system. Hopefully they didn't decimate a extraterrestrial lifeform in the process (makes you wonder about the dinosaurs and those theoretical comets). Not a very polite way of starting a War of the Worlds scenario.

Back on earth, humans, with their own eccentric ways of commemorating such occasions, incorporated computer simulations of the Deep Impact probe in flight with footage of Billy Haley and His Comets in a music video:


and one promptly sued NASA for "disrupting the natural balance of forces in the universe".

Now, NASA is preparing for its first mission since the Columbia disaster in February 2003. Liftoff is set for 3:51 p.m. ET.

I've always been inordinately fascinated by any exploration of the universe. There is something terribly humbling about the vastness of space and our inability to even venture to a few specks of it in the enormous beach.

Of course, any study of the cosmos is humbling. As far as my layman's understanding of it goes, the world is not quite the neatly catalogued, efficiently filed away, certain place that physics, chemistry, biology or geology school textbooks would have us believe: here we are, sitting on a speck whose age we cannot determine with any accuracy. We have theories about how it manages to rotate around the sun without smashing into it or be thrown off into deep space, but they are only guesstimates until a better theory comes along. We have theories about the creatures that lived many years before us but even with the very few complete fossils we have, we sometimes manage to jumble up their body parts in recontruction and stick their thumbs on their noses. The theory of plate tectonics is fairly recent and wasn't accepted until the 1980s. We're not quite sure what the earth is made of and what we're sitting on and since no one has seen the interior of the earth, what is taught as geological fact is mere postulation.

Then there is the uncertainty of how life began, and even if we just concentrate on the life that is on this planet at this moment, we have barely scratched the surface of the enormous amounts of creatures and species that exist. And even if we just concentrate on one species, the homo sapiens, we hardly understand the whys and wherefores of its physiology, anatomy, genetics, race and ethnic differentiations, sexualities, intelligence, psychology, emotions, biological disease...

The pompousity of our current understanding is embarrassing given that it is only infinitely and picayunically paltry. The cosmos is so infinite and complex, yet to us who believe, it is very simple:
By the word of the LORD the heavens were made,
and by the breath of his mouth all their host.
He gathers the waters of the sea as a heap;
he puts the deeps in storehouses.

Let all the earth fear the LORD;
let all the inhabitants of the world stand in awe of him!
For he spoke, and it came to be;
he commanded, and it stood firm.

The LORD brings the counsel of the nations to nothing;
he frustrates the plans of the peoples.
The counsel of the LORD stands forever,
the plans of his heart to all generations.
Blessed is the nation whose God is the LORD,
the people whom he has chosen as his heritage!

The LORD looks down from heaven;
he sees all the children of man;
from where he sits enthroned he looks out
on all the inhabitants of the earth,
he who fashions the hearts of them all
and observes all their deeds.

The king is not saved by his great army;
a warrior is not delivered by his great strength.
The war horse is a false hope for salvation,
and by its great might it cannot rescue.

Behold, the eye of the LORD is on those who fear him,
on those who hope in his steadfast love,
that he may deliver their soul from death
and keep them alive in famine.

Our soul waits for the LORD;
he is our help and our shield.
For our heart is glad in him,
because we trust in his holy name.
Let your steadfast love, O LORD, be upon us,
even as we hope in you. (Psalm 33:6-22)

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